After completing her studies and moving to New York City to pursue a modeling career full time, Doutzen began appearing on the runways in New York, London, Paris and Milan. She has been featured on the covers of Italian, German and Japanese Vogue, Numero, Dazed and Confused, while working consistently with the industry's top photographers including Steven Meisel, Inez Van Lamsweerde and Vinoodh Matadin, Patrick Demarchelier, Craig McDean, Glen Luchford, Daniel Jackson, Solve Sundsbo and Terry Tsiolis.
Doutzen has shot campaigns for Valentino, Calvin Klein, Dolce & Gabbana, Calvin Klein's fragrance Eternity and is under contract with L'Oreal. She is also involved with non-profit work, most notably with the World Wildlife Fund, and hopes to work with humanitarian causes in the future.