Du Juan studied dance and traditional opera at the prestigious Shanghai Dance School from the age of eight. When she grew too tall for ballet she entered a national modelling competition where she took the top prize. Soon after she was awarded "Model of the Year" at the 2004 China Fashion Awards and named "China's Top 10 Model" by the China Fashion Federation. Shanghai Tang, the first Chinese global luxury brand and Lane Crawford, Asia's premier luxury retail giant, both signed her on for their advertising campaigns and since 2005 she has been a quality ambassador for Perles de Tahiti.
Du Juan debuted at the Spring 2006 Haute Couture shows in Paris where she walked for top design houses - Chanel, Valentino, Givenchy, Jean Paul Gaultier and Anne Valerie Hash. She has worked with renowned photographers such as Peter Lindberg, Patrick Demarchelier, Mario Testino, Mert and Marcus, David Sims, Paolo Roversi, Mario Sorrenti, Karl Lagerfeld, Juergen Teller and Craig McDean. She is also featured regularly in such influential magazines as French Vogue, Italian Vogue, W and Allure.
Du Juan features frequently in China Vogue, with three covers including the inaugural issue and at least one major fashion editorial in every single issue since the launch of the magazine in September 2005.
In the Fall of 2006 she walked down 43 runways for top brands such as Louis Vuitton, Yves Saint Laurent, Roberto Cavalli, Hermes, Kenzo, Bottega Veneta, Emmanuel Ungaro, Dries Van Noten, Oscar De La Renta and Bagley Miswchka. Style.com named her one of its top ten models of the season. She has appeared in global advertising campaigns for five major international brands - Louis Vuitton, Yves Saint Laurent, Roberto Cavalli, Gap and Swarovski.