Doillon made her film debut at five as Jane Birkin's on-screen daughter in a romantic drama entitled Kung fu master , but her first starring role arrived in 1997 when she played the rebellious adolescent in the film Trop peu d'amour , directed by her father.
At 16, she began an unexpected career as a model for Eres, Missoni and Givenchy and for the "Eau Torride" perfume, and she appears in the current Miu Miu advertising campaign.
Lou has often played tempestuous, volcanic roles such as Blanche , a romantic and sexy costume film from 2002. She next appeared with Charlotte Rampling, who played her mother, in Summer Things. In 2003, she was Miss Pepys , co-starring with Steve Coogan for the BBC, and she appeared in Saint Ange ,her first French-American horror flick, with Virginie Ledoyen.
In 2006 Lou just finished a film written and directed by Douglas Buck, co-starring Chloé Sévigny and Stephen Rea. "Sisters" is the remake of "The Two Sisters", directed by Brian de Palma in 1973. She will soon appear in Boxes , the story of a family, directed by her mother Jane Birkin and starring Geraldine Chaplin, John Hurt, and Natacha Régnier.